Department of Nephrology and Transplantation Medicine
Wrocław Medical University
Borowska 213, 50-556 Wrocław, POLAND
tel.: +48 71 733 25 00, +48 71 733 25 01, faks: + 48 71 733 25 09
e-mail: klinef@am.centrum.pl
Head: Prof. Marian Klinger, MD, PhD tel. +48 71 733 25 00; e-mail: klinef@am.centrum.pl
Staff of the Department
Publications
MAIN AREAS OF RESEARCH
PRIMARY AND SECONDARY GLOMERULONEPHRITIS.

Severity of clinical symptoms (hypertension and proteinuria) and activity and chronicity indices in renal biopsy
studies - impact on long-term course of primary glomerulonephritis.

The significance of IgG/IgM ratio in daily proteinuria and heparanase excretion for the treatment response and long-
term prognosis in different types of glomerulonephritis.

Immunosupressive programs in the treatment of primary and secondary (lupus nephritis, vasculitis)
glomerulonephritis - efficacy in long-term follow-up.

The involvement of neutrophils in the pathogenesis of the primary and secondary glomerulonephritis.
Apoptosis of neutrophils in systemic vasculitis.

Localization of elastase deposits in renal tissue and assessment of relationship with urinary excretion.

Genetic and immunologic background of primary and secondary glomerolunephritis.

Genetic and endocrine background of diabetic nephropathy.

Pathogenesis and prognostic markers of lupus nephritis.
HAEMODIALYSIS.

Factors affecting cardiovascular morbidity and mortality of haemodialysis population - the significance of low fetuin-
A level, hyperhomocysteinemia, ADMA (acyclic dimethylarginine), low-molecular protein-bound toxins (inoxyl
sulphate, p-cresol, phenol) and inflammatory indices (IL-1, IL-6, IL-18 a.o.) in relation with pulse wave velocity
(PWV) measurements.

Vascular access creation in high risk, elderly and diabetic, haemodialysis patients - application of self-developed
method of the native arteriovenous fistula formation with the use of perforating vein connected end-to-end to radial
artery in patient with destroyed superficial veins.

Elaboration of the method of the wrist native arteriovenous fistula superficialization in obese patients.

Assessment of physical exercise influence on biochemical and clinical parameters in hemodialysed patients.

PERITONEAL DIALYSIS.

Peritoneal dialysis treatment of high risk patients (diabetics, with cardiovascular instability) - value of the PD-
treatment and its impact on morbidity and mortality.

Patients with high permeability of peritoneal membrane - efficacy of continuous cyclic peritoneal dialysis.

Removal of the low-molecular protein-bound toxins - comparison between peritoneal dialysis and haemodialysis.

Quality of life of patients on HD- and CAPD-treatment.

Individualization of renal replacement therapy in the elderly and diabetic patients.

Cardiovascular system in patients treated with various methods of renal replacement.

Peritoneal dialysis as last choice therapy in patients without vascular access.

Prolongation of peritoneal dialysis treatment as a renal replacement therapy.
KIDNEY ALLOGRAFTS.

Urine cytodiagnostics in monitoring of renal allograft injury.

Chronic allograft nephropathy - the effect of MMF-treatment.

Viral infections following renal transplantation (CMV, HSV, polyoma).

The role of genetic polymorphism of interleukins and co-stimulatory molecules.

The effect of hiperlipidaemia, hyperuricemia and endothelial biomarkers on renal function in kidney allograft
recipients.

Optimization of immunosupression after renal transplantation e.g. early steroid withdrawal in the kidney graft
recipients and replacement of calcineurin inhibitors by less nephrotoxic immunosupressive agents - conversion
criteria, new immunosuppressive drugs.

Structural and immunological changes in transplanted kidneys - the influence of cold ischemia, warm ischemia and
reperfusion. Characterisitics of expression of cytokines and growth factors in kidney allograft biopsies in relation to
ischaemic/reperfusion injury, acute and chronic allograft rejection and calcineurin inhibitors toxicity.

Application of extracorporeal photopheresis for immune tolerance induction and anti-rejection therapy.

Cytokine and adhesion molecules gene polymorphism and intensity of acute and chronic kidney allograft rejection.

Vascular wall injury molecules at genetic and protein level and their influence on long-term kidney transplant out-
come.
Assessment of the kidney transplant recipients alloreactivity using ELISPOT assay.

Variability in donor-specific alloantibody production after transplantation.

CTLA4 and CD40L expression on T lymphocytes in kidney transplant recipients.

Indices of immunologic tolerance in the recipients with long-term functioning graft on minimal immunosupression.

Regulatory cells subpopulations variations and expression of related immune molecules in the post-transplantation
period. Assessment of regulatory cell engagement in the immune tolerance development.

Oxidative stress impact on chronic allograft nephropathy.